Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors

…, M Lizarzaburu, S Turcotte, T Lee, J Greenberg…

文献索引：Du, Xiaohui; Lizarzaburu, Mike; Turcotte, Simon; Lee, Taeweon; Greenberg, Joanne; Shan, Bei; Fan, Peter; Ling, Yun; Medina, Julio C.; Houze, Jonathan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3774 - 3779

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被引用次数: 8

摘要

Abstract Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties of this series of SGLT2 inhibitors. From these efforts, compounds 28 and 32 have improved solubility and pharmacokinetic properties compared to compound 1