Synthesis and antitumor activity of a new class of Pyrazolo [4, 3-e] pyrrolo [1, 2-a][1, 4] diazepinone analogs of pyrrolo [1, 4][2, 1-c] benzodiazepines

…, D Simoni, M Bergomi, E Menta, S Spinelli

文献索引：Baraldi; Leoni; Cacciari; Manfredini; Simoni; Bergomi; Menta; Spinelli Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4329 - 4337

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被引用次数: 31

摘要

A new class of pyrrolo [l, 4lbenzodiazepine (PBD) analogues featuring a pyrazolo [4, 3-e] pyrrolo-[l72-al [l, 4] diazepinone ring system has been designed and synthesized. These compounds, 2a-0, are characterized by the substitution of the aromatic A ring, characteristic of the PBDs, with a disubstituted pyrazole ring bearing alkyl and benzyl substituents at N6 or N7 and alkyl or carbomethoxy substituents at c8. Biological evaluation revealed an ...