3-[(2-Ethoxyphenoxy) methyl] piperidine derivatives. Synthesis and antidepressant activity

…, A Lucacchini, B Macchia, F Macchia…

文献索引：Balsamo, A.; Giorgi, I.; Lapucci, A.; Lucacchini, A.; Macchia, B.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 222 - 225

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被引用次数: 6

摘要

The 3-1 (2-ethoxyphenoxy) methyl] piperidine derivatives 3-5 were synthesized and screened as potential antidepressant agents by the reserpine interaction test in mice and the evaluation of reuptake inhibition of biogenic amines in pig brain synaptosomal fractions. In addition, their anticonvulsant activity, tested by pentylenetetrazole antagonism, and approximate acute toxicity were evaluated. In vivo and in vitro tests showed that ...