Synthesis, antimalarial activity, and molecular modeling of new pyrrolo [1, 2-a] quinoxalines, bispyrrolo [1, 2-a] quinoxalines, bispyrido [3, 2-e] pyrrolo [1, 2-a] pyrazines …

…, R Déprez-Poulain, I Forfar-Bares…

文献索引：Guillon, Jean; Grellier, Philippe; Labaied, Mehdi; Sonnet, Pascal; Leger, Jean-Michel; Deprez-Poulain, Rebecca; Forfar-Bares, Isabelle; Dallemagne, Patrick; Lemaitre, Nicolas; Pehourcq, Fabienne; Rochette, Jacques; Sergheraert, Christian; Jarry, Christian Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1997 - 2009

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被引用次数: 108

摘要

Three pyrrolo [1, 2-a] quinoxalines, 15 bispyrrolo [1, 2-a] quinoxalines, bispyrido [3, 2-e] pyrrolo [1, 2-a] pyrazines, and bispyrrolo [1, 2-a] thieno [3, 2-e] pyrazines were synthesized from various substituted nitroanilines or nitropyridines and tested for their in vitro activity upon the erythrocytic development of Plasmodium falciparum strains with different chloroquine-resistance status. Bispyrrolo [1, 2-a] quinoxalines showed superior ...