Tetrahedron

Synthesis of functionalized 4-phenyl-pyridines via electrochemically prepared organozinc reagents

E Le Gall, C Gosmini, JY Nédélec, J Périchon

文献索引：Gall, Erwan Le; Gosmini, Corinne; Nedelec, Jean-Yves; Perichon, Jacques Tetrahedron, 2001 , vol. 57, # 10 p. 1923 - 1927

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被引用次数: 26

摘要

The efficient and convenient synthesis of various functionalized 4-phenyl-pyridines 2 is described. The key step of the procedure is the electrochemical formation of aromatic organozinc reagents 1 and their coupling with pyridinium salts. Intermediate 1, 4- dihydropyridines are oxidized using mild conditions to provide functionalized 4-phenyl- pyridines in moderate to high overall yields.