Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists

…, H Yamamoto, H Okada, T Maruyama, H Nakai…

文献索引：Naganawa, Atsushi; Matsui, Toshiaki; Ima, Masaki; Yoshida, Koji; Tsuruta, Hiroshi; Yamamoto, Shingo; Yamamoto, Hiroshi; Okada, Hiroki; Maruyama, Takayuki; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7774 - 7789

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被引用次数: 11

摘要

A series of 4-[(2-{isobutyl [(5-methyl-2-furyl) sulfonyl] amino} phenoxy) methyl] benzoic acids and 4-({2-[isobutyl (1, 3-thiazol-2-ylsulfonyl) amino] phenoxy} methyl) benzoic acids were synthesized and evaluated for their EP receptor affinities and EP1 receptor antagonist activities. Further structural optimization was carried out to reduce inhibitory activity against hepatic cytochrome P450 isozymes, which could represent a harmful potential drug ...