Biomacromolecules

Tuning Gelation Time and Morphology of Injectable Hydrogels Using Ketone–Hydrazide Cross-Linking

M Patenaude, S Campbell, D Kinio, T Hoare

文献索引：Patenaude, Mathew; Campbell, Scott; Kinio, Dennis; Hoare, Todd Biomacromolecules, 2014 , vol. 15, # 3 p. 781 - 790

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被引用次数: 15

摘要

Injectable, covalently in situ forming hydrogels based on poly (N-isopropylacrylamide) have been designed on the basis of mixing hydrazide-functionalized nucleophilic precursor polymers with electrophilic precursor polymers functionalized with a combination of ketone (slow reacting) and aldehyde (fast reacting) functional groups. By tuning the ratio of aldehyde: ketone functional groups as well as the total number of ketone groups in the ...