Selective synthetic routes to sterically hindered unsymmetrical diaryl ketones via arylstannanes

MJ Lo Fiego, GF Silbestri, AB Chopa…

文献索引：Lo Fiego, Marcos J.; Badajoz, Mercedes A.; Silbestri, Gustavo F.; Lockhart, Maria T.; Chopa, Alicia B. Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 9184 - 9187

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被引用次数: 24

摘要

Bulky arylstannanes and bulky aroyl chlorides are good reaction partners for the synthesis of two-, three-, and even four-ortho-substituted benzophenones, in good to excellent isolated yields (47− 91%). Three simple and direct routes, with differential advantages, are proposed:(i) a catalyst-free protocol, in o-dichlorobenzene (ODCB) at 180° C;(ii) a room temperature protocol, using AlCl3 (0.5 equiv), in dichloromethane (DCM); and (iii) a ...