Preparative production of optically active esters and alcohols using esterase-catalyzed stereospecific transesterification in organic media

B Cambou, AM Klibanov

文献索引：Cambou, Bernard; Klibanov, Alexander M. Journal of the American Chemical Society, 1984 , vol. 106, # 9 p. 2687 - 2692

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被引用次数: 302

摘要

Abstract: A novel enzymatic approach to the production of optically active alcohols and esters from racemates is developed. It involves the use of esterase catalyzed transesterifications carried out in biphasic aqueous-organic mixtures. Water-insoluble substrates constitute the organic phase, while the enzyme is located in the aqueous phase. Since the fraction of the latter phase can be made very low, such an arrangement solves ...