Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4, 5-diaryl isoselenazoles

M Scholz, HK Ulbrich, G Dannhardt

文献索引：Scholz, Michael; Ulbrich, Holger K.; Dannhardt, Gerd European Journal of Medicinal Chemistry, 2008 , vol. 43, # 6 p. 1152 - 1159

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被引用次数: 16

摘要

The aim of this study was to investigate 4, 5-diaryl isoselenazoles as multiple target non- steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds. Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting ...