Absolute configuration of the four stereoisomers of valnoctamide (2-ethyl-3-methyl valeramide), a potentially new stereospecific antiepileptic and CNS drug

M Roeder, O Spiegelstein, V Schurig, M Bialer…

文献索引：Roeder, Michael; Spiegelstein, Ofer; Schurig, Volker; Bialer, Meir; Yagen, Boris Tetrahedron Asymmetry, 1999 , vol. 10, # 5 p. 841 - 853

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被引用次数: 20

摘要

Valnoctamide (2-ethyl-3-methyl valeramide, Nirvanil®, VCD), a mild tranquilizer endowed with anticonvulsant properties, exhibits diastereoselective and enantioselective pharmacokinetics in healthy subjects and epileptic patients. The purpose of this paper is to assign the absolute configuration of the four VCD stereoisomers and to describe the stereoselective synthesis used to prepare two-key VCD stereoisomers. We have ...