Reactivity and mechanism of the antitumor effect of triazines

VI Nifontov, NP Bel'skaya, VA Chernov…

文献索引：Nifontov, V. I.; Bel'skaya, N. P.; Chernov, V. A.; Ershova, Yu. A.; Validuda, G. I.; et al. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 9 p. 592 - 596 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 9 p. 1037 - 1041

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摘要

5-(3, 3-Dimethyl-l-triazeno) imidazole-4-carboxamide (dicarbazine)(I), synthesized by J. Shealy et al. in 1961 [12], has now found clinical use in the treatment of melanoma. However, the therapeutic effectiveness of the preparation in monochemotherapy, as well as in combination with antitumor agents, is limited by the short lifetime of the enzymatically formed active metabolite 5-(3-methyl-l-triazeno) imidazole-4-carboxamide (II), which is a ...