Structure??based design and synthesis of the first weak non??phosphate inhibitors for IspF, an enzyme in the non??mevalonate pathway of isoprenoid biosynthesis

…, C Eberle, F Diederich, S Lauw, F Rohdich…

文献索引：Baumgartner, Corinne; Eberle, Christian; Diederich, Francois; Lauw, Susan; Rohdich, Felix; Eisenreich, Wolfgang; Bacher, Adelbert Helvetica Chimica Acta, 2007 , vol. 90, # 6 p. 1043 - 1068

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被引用次数: 25

摘要

Abstract In this paper, we describe the structure-based design, synthesis, and biological evaluation of cytosine derivatives and analogues that inhibit IspF, an enzyme in the non- mevalonate pathway of isoprenoid biosynthesis. This pathway is responsible for the biosynthesis of the C 5 precursors to isoprenoids, isopentenyl diphosphate (IPP, 1) and dimethylallyl diphosphate (DMAPP, 2; Scheme 1). The non-mevalonate pathway is the ...