Mannich bases of 4-phenyl-3-buten-2-one. A new class of antiherpes agent

ML Edwards, HW Ritter, DM Stemerick…

文献索引：Edwards, M.L.; Ritter, H.W.; Stemerick, D.M.; Stewart, K.T. Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 431 - 436

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被引用次数: 35

摘要

The morpholine Mannich base of 4-phenyl-3-buten-2-one was found to have activity in model infections of herpes simplex. The activity was essentially equivalent to that of disodium phosphonoacetate. This paper presents the biological activity and synthesis of a series of derivatives and analogues of the lead compound.