Tetrahedron

Preparation of N-arylpiperazines and other N-aryl compounds from aryl bromides as scaffolds of bioactive compounds

M Romero, Y Harrak, J Basset, L Ginet, P Constans…

文献索引：Romero; Harrak; Basset; Ginet; Constans; Pujol Tetrahedron, 2006 , vol. 62, # 38 p. 9010 - 9016

全文：HTML全文

被引用次数: 26

摘要

Aryl bromides are coupled with N-compounds to give the corresponding arylamines in the presence of a palladium catalyst, a suitable ligand, and a weak base. The catalysts perform well for a large number of different starting material combinations at 100–150° C with drops of toluene or without solvent, and with low catalyst levels (0.12 mol% Pd). The low catalyst amount makes the process environment friendly.