Autotaxin structure–activity relationships revealed through lysophosphatidylcholine analogs

…, DA Osborne, PK Bridson, DL Baker, AL Parrill

文献索引：North, E. Jeffrey; Osborne, Daniel A.; Bridson, Peter K.; Baker, Daniel L.; Parrill, Abby L. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 9 p. 3433 - 3442

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被引用次数: 25

摘要

Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to form the bioactive lipid lysophosphatidic acid (LPA). LPA stimulates cell proliferation, cell survival, and cell migration and is involved in obesity, rheumatoid arthritis, neuropathic pain, atherosclerosis and various cancers, suggesting that ATX inhibitors have broad therapeutic potential. Product feedback inhibition of ATX by LPA has stimulated structure–activity ...