Synthesis of (–)??(S)??Norlaudanosine,(+)??(R)??O, O??Dimethylcoclaurine, and (+)??(R)??Salsolidine by Alkylation of an α??Aminonitrile

F Werner, N Blank, T Opatz

文献索引：Werner, Frank; Blank, Nancy; Opatz, Till European Journal of Organic Chemistry, 2007 , # 23 p. 3911 - 3915

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被引用次数: 19

摘要

Abstract A short asymmetric synthesis of 1-substituted 1, 2, 3, 4-tetrahydroisoquinoline alkaloids by deprotonation of an unprotected α-aminonitrile and alkylation of the resulting carbanion followed by spontaneous elimination of HCN and asymmetric reduction is described.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)