Synlett

Superacid activated condensation of parabanic acid and derivatives with arenes. A new synthesis of phenytoin and 5, 5-diarylhydantoins

DA Klumpp, KY Yeung, GKS Prakash, GA Olah

文献索引：Klumpp, Douglas A.; Yeung, Ka Yeun; Prakash, G. K. Surya; Olah, George A. Synlett, 1998 , # 8 p. 918 - 920

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被引用次数: 21

摘要

Abstract: A new synthetic route to phenytoin and 5, 5-diarylhydantoins is reported. Parabanic acid is converted to the 5, 5-diarylhydantoins (65-98% yield) from CF3SO3H and arenes. Deuterium substituted products are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.