Synthesis of 3-Amino-5H-pyrido [4, 3-b] indoles, Carcinogenic γ-Carbolines

H Akimoto, A Kawai, H Nomura

文献索引：Akimoto, Hiroshi; Kawai, Akiyoshi; Nomura; Hiroaki Bulletin of the Chemical Society of Japan, 1985 , vol. 58, p. 123 - 130

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被引用次数: 15

摘要

The carcinogenic γ-carbolines 3-amino-1, 4-dimethyl-5H-pyrido [4, 3-b] indole (1) and 3- amino-1-methyl-5H-pyrido [4, 3-b] indole (2) were synthesized efficiently by the following procedures. The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2- indolyl) alkanoic acids to 1, 2-dihydro-γ-carbolines. This was followed by dehydrogenation to the γ-carbolinecarboxylates and conversion of the ester group to the carboxyl and ...