Liebigs Annalen der Chemie

4??(1??Azi??2, 2, 2??trifluoroethyl) benzoic Acid, a Highly Photolabile Carbene Generating Label Readily Fixable to Biochemical Agents

M Nassal

文献索引：Nassal, Michael Liebigs Annalen der Chemie, 1983 , # 9 p. 1510 - 1523

全文：HTML全文

被引用次数: 82

摘要

Abstract The title compound is synthesized starting from either 4-bromobenzyl tert- butyldimethylsilyyl ether (5b) or 4-bromobenzyl tert-butyl ether (5c) or–most simply–from 4- bromotoluene (5a). In the first step Br was replaced by Li using n-butyllithium, then the organometallic compounds were converted into the respective trifluoroacetophenones 6a–c with N-trifluoroacetylpiperidine. The azi moiety (diazirine) was prepared from the oximes ...