Molecules

Simple and efficient microwave assisted N-alkylation of isatin

MS Shmidt, AM Reverdito, L Kremenchuzky, IA Perillo…

文献索引：Shmidt, Maria Sol; Reverdito, Ana Maria; Kremenchuzky, Lautaro; Perillo, Isabel Amalia; Blanco, Maria Mercedes Molecules, 2008 , vol. 13, # 4 p. 831 - 840

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被引用次数: 50

摘要

Abstract: We present herein the results of microwave promoted N-alkylations of isatin (1) with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried out under different conditions, always employing methodologies compatible with MW assisted chemistry. Generation of isatin anion employing diverse bases and solvents or using the preformed isatin sodium salt was tested. The best results were achieved using K 2 CO 3 or ...