Regioselective Synthesis of 6??Prenylpolyhydroxyisoflavone (Wighteone) and Wighteone Hydrate with Hypervalent Iodine

…, Y Kawamura, M Tsukayama, M M. Hossain

文献索引：Hossain, Mohammad M.; Tokuoka, Takanori; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao Synthetic Communications, 2006 , vol. 36, # 9 p. 1201 - 1211

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被引用次数: 12

摘要

Abstract The oxidative rearrangement of 3′??iodotetraalkoxychalcone with [hydroxyl (tosyloxy) iodo] benzene, followed by cyclization of the resultant acetal gave 6?? iodotrialkoxyisoflavone. The coupling reaction of the isoflavone with 2??methyl??3??butyn??2??ol gave 6??alkynylisoflavone, whose hydrogenation gave wighteone hydrate. Wighteone was synthesized by dehydration of wighteone hydrate.