Tetrahedron letters

A short and efficient synthesis of DE-A, B (22E, 24S)-8β-(benzoyloxy)-25-hydroxyergost-22-ene a valuable intermediate in the total synthesis of 25-hydroxylated …

JC Hanekamp, RB Rookhuizen, HLA Heuvel, HJT Bos…

文献索引：Hanekamp, Jaap C.; Rookhuizen, Rob Boer; Heuvel, Henry L. A. V. D.; Bos, Hendrik J. T.; Brandsma, Lambert Tetrahedron Letters, 1991 , vol. 32, # 39 p. 5397 - 5400

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被引用次数: 5

摘要

The reaction speed was greatly enhanced using dry THF instead of aceton. Perhaps an explanation might be the higher boiling point of THF, greater solubility of Lil (mostly Nal or Kl are used), and the amount of water dissolved in the solvent. We used THF distilled from sodium. The reaction was finished within 15 minutes. ... The E/Z ratio of the Wittig reaction was exceptionally high namely 100:0 (according to 1 H and 13 C NMR spectroscopy). ... Cookies are used by ...