Classical and dynamic resolution of 1-amino-3-methyl-1, 3, 4, 5-tetrahydrobenzo [d] azepin-2-one

…, TM Koenig, S McDaniel, JS Nissen, JE Audia

文献索引：Mitchell, David; Hay, Lynne A.; Koenig, Thomas M.; McDaniel, Stacey; Nissen, Jeffrey S.; Audia, James E. Tetrahedron Asymmetry, 2005 , vol. 16, # 23 p. 3814 - 3819

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被引用次数: 9

摘要

Two efficient production processes of enantioenriched 1-amino-3-methyl-1, 3, 4, 5- tetrahydro-benzo [d] azepin-2-one 1 were achieved using the readily available starting materials. A key step in the methodologies is a classical resolution or a dynamic resolution that provides excellent chemical (> 80%) yields and enantiomeric excesses (> 99.8% ee). The classical resolution was developed on a preparative scale while the dynamic ...