Carbon Monoxide??Free One??Step Synthesis of Isoindole??1, 3??diones by Cycloaminocarbonylation of o??Haloarenes Using Formamides

…, YS Wagh, KD Bhatte, BM Bhanage

文献索引：Sawant, Dinesh N.; Wagh, Yogesh S.; Bhatte, Kushal D.; Bhanage, Bhalchandra M. Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5489 - 5494

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被引用次数: 5

摘要

Abstract A new carbon monoxide-free, solvent-free, single step protocol for the synthesis of isoindole-1, 3-diones from o-haloarenes using palladium acetate and xantphos catalysis is reported. The wider applicability of this protocol for several types of o-iodoarenes and a few o-bromoarenes makes it attractive. Aryl iodides and aryl bromides provided moderate to excellent yields of up to 93%.

~79%

~70%

~90%

~77%

~94%

~73%

7291-00-1

4-甲氧基-N,N-二甲基-苯甲酰胺

~91%

~70%

~72%

~75%

~86%

~92%

~70%

~94%

~97%

~72%

~84%

~53%

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