Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors

…, BG Szczepankiewicz, M Liu, C Kosogof…

文献索引：Zhao, Hongyu; Serby, Michael D.; Xin, Zhili; Szczepankiewicz, Bruce G.; Liu, Mei; Kosogof, Christi; Liu, Bo; Nelson, Lissa T. J.; Johnson, Eric F.; Wang, Sanyi; Pederson, Terry; Gum, Rebecca J.; Clampit, Jill E.; Haasch, Deanna L.; Abad-Zapatero, Cele; Fry, Elizabeth H.; Rondinone, Cristina; Trevillyan, James M.; Sham, Hing L.; Liu, Gang Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4455 - 4458

全文：HTML全文

被引用次数: 65

摘要

C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly ...