Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles

…, A Yamashita, N Zhang, D Powell, J Weber…

文献索引：Boschelli, Diane H; Wang, Daniel Y; Ye, Fei; Yamashita, Ayako; Zhang, Nan; Powell, Dennis; Weber, Jennifer; Boschelli, Frank Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 15 p. 2011 - 2014

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被引用次数: 34

摘要

Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2, 5-, 3, 5-or 2, 4-pattern, potent inhibition of Src kinase activity was observed.