Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8- amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.
![2-[5-[(6-methoxyquinolin-8-yl)amino]pentyl]isoindole-1,3-dione结构式](https://image.chemsrc.com/caspic/331/6623-94-5.png)
![1H-Isoindole-1,3(2H)-dione,2-[3-[(6-methoxy-8-quinolinyl)amino]propyl]结构式](https://image.chemsrc.com/caspic/416/7399-04-4.png)
![N-(6-methoxy-[8]quinolyl)-pentanediyldiamine结构式](https://image.chemsrc.com/caspic/380/82350-99-0.png)
![1H-Isoindole-1,3(2H)-dione,2-[2-[(6-methoxy-8-quinolinyl)amino]ethyl]结构式](https://image.chemsrc.com/caspic/422/6947-84-8.png)