Synthesis

A Simple and Efficient Synthesis of N-Substituted Cyclohex-3-enamines

M Álvarez-Pérez, J Marco-Contelles

文献索引：Alvarez-Perez, Monica; Marco-Contelles, Jose Synthesis, 2009 , # 21 p. 3649 - 3653

全文：HTML全文

被引用次数: 2

摘要

Abstract A straightforward preparation of N-substituted cyclohex-3-enamines starting from the commercially available trans-4-aminocyclohexanol hydrochloride is described. Cyclohex- 3-enamino-functionalized compounds have proven to be interesting intermediates in medicinal chemistry. The method here described is cheaper, more scalable and tolerant of a broader variety of functional groups than those found in the literature for this type of ...