Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors

LF Zeng, HS Zhang, YH Wang, T Sanchez…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4521 - 4524

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被引用次数: 36

摘要

... Bioorganic & Medicinal Chemistry Letters. ... The coupling of nitrile sulfide with methyl propiolate afforded almost equal ratio isomers 16 and 17, which were distinguished by the chemical shift of the hydrogen on the isothiazole ring. ...