Abstract: The discovery of a dipeptide ester, L-Asp-L-Phe-OMe, having an intense sweet taste is reported. Investigation of structure-taste relationships showed that L-aspartic acid is critical for sweetness but that considerable modification of the phenylalanine portion can be tolerated. ynthetic sweetening agents have been important sub-S stances since the discovery of saccharin in 1879.'In recent years, particularly because of emphasis on ...
