Tetrahedron

Facile synthesis of 3, 5-diaryl-1, 2, 4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates

K Sudheendran, D Schmidt, W Frey, J Conrad…

文献索引：Sudheendran, Kavitha; Schmidt, Dietmar; Frey, Wolfgang; Conrad, Juergen; Beifuss, Uwe Tetrahedron, 2014 , vol. 70, # 8 p. 1635 - 1645

全文：HTML全文

被引用次数: 11

摘要

Abstract Two methods for the synthesis of 3, 5-diaryl-1, 2, 4-triazoles, both domino reactions, are reported. The first procedure, the Cu (OTf) 2-catalyzed reaction between two amidines using NaHCO 3 as a base, 1, 10-phenanthroline as an additive and K 3 [Fe (CN) 6]/atmospheric oxygen as the oxidant, delivers 3, 5-diaryl-1, 2, 4-triazoles with yields up to 68%. The second procedure for the synthesis of 3, 5-diaryl-1, 2, 4-triazoles with yields up ...