NOC Chemistry for Tuberculosis—Further Investigations on the Structure–Activity Relationships of Antitubercular Isoxazole??3??carboxylic Acid Ester Derivatives

…, B Wan, S Cho, SG Franzblau, AP Kozikowski

文献索引：Pieroni, Marco; Lilienkampf, Annamaria; Wang, Yuehong; Wan, Baojie; Cho, Sanghyun; Franzblau, Scott G.; Kozikowski, Alan P. ChemMedChem, 2010 , vol. 5, # 10 p. 1667 - 1672

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被引用次数: 8

摘要

Tuberculosis (TB) is a frequent infectious disease that primarily involves the lungs and that is spread throughout the world by Mycobacterium tuberculosis (Mtb). Both morbidity and mortality related to this disease remain high—each year, approximately nine million people are diagnosed with active TB and 1.6 million die of the disease.[1] The rapid emergence of multidrug-resistant Mtb (MDR-TB) and extensively-resistant Mtb (XDR-TB) strains, along ...