Abstract: Synthesis of a great variety of quinoline derivatives has been developed by lithiation of N-pivaloylanilines with sec-BuLi, formylation with DMF, and subsequent condensation with active methylene groups of aldehydes or ketones (KHMDS). The pivaloyloxy group is eliminated during the one-pot procedure in most cases. The scope of the reaction has been studied, showing that the method is limited by the nature of ...
