Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs

…, Y Mei Liu, X Yao, ZT Zheng, X Luo, DF Liao

文献索引：Zheng, Xing; Zhao, Fei Fei; Liu, Yun Mei; Yao, Xu; Zheng, Zi Tong; Luo, Xing; Liao, Duan Fang Medicinal Chemistry, 2010 , vol. 6, # 1 p. 6 - 8

全文：HTML全文

被引用次数: 16

摘要

A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2, 4- dihydroxyacetophenone, 2, 4, 6-trihydroxy-acetophenone, using modified Baker- Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.