A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2, 4- dihydroxyacetophenone, 2, 4, 6-trihydroxy-acetophenone, using modified Baker- Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
[Krayushkin, Mikhail M.; Levchenko, Konstantin S.; Yarovenko, Vladimir N.; Christoforova, Ludmila V.; Barachevsky, Valery A.; Puankov, Yury A.; Valova, Tatyana M.; Kobeleva, Olga I.; Lyssenko New Journal of Chemistry, 2009 , vol. 33, # 11 p. 2267 - 2277]
