Abstract: Considerations of atom economy drive a search for reactions that are simple additions which, performed intramolecularly, are cycloisomerizations. Exposure of acyclic enediynes to a catalyst generated by mixing a Pd (0) complex with acetic acid normally in the presence of a phosphine ligand creates [5.6. 5] and [6.6. 5] tricycles with extraordinary diastereoselectivity of remote stereogenic centers. Effects of substituents on the tethers as ...
