Tetrahedron

Models of folate coenzymes 16: Chemical modelling of the thymidylate synthase reaction. Evidence for an “exocyclic methylene intermediate” analogue, which is …

PFC Van Der Meij, RD Lohmann, ER De Waard…

文献索引：Meij, Paul F. C. van der; Lohmann, Ruth D.; Waard, Eduard R. De; Chen, Tjoe B. R. A.; Pandit, Upendra K. Tetrahedron, 1986 , vol. 42, # 14 p. 3921 - 3930

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被引用次数: 8

摘要

Reactions of 6-amino-, 6-alkylamino-and 6-anilino-l, 3-dimethyluracils (1a-e) with 3, 4- diphenyl-1-tosylimidazolidine (2), in the presence of acid, lead to the formation of products which are derived from an “exocyclic methylene intermediate” analogous to the one formed in the thymidylate synthase reaction. The intermediate has been identified by (a) spectral studies,(b) formation of adducts with dihydropyridine and dihydroquinonline derivatives ...