Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT 2A, 5-HT 2C, and the serotonin transporter as a potential antidepressant

…, HJ Kim, ME Jung, EJ Son, AN Pae, J Kim, J Lee

文献索引：Kim, Jong Yup; Kim, Deukjoon; Kang, Suk Youn; Park, Woo-Kyu; Kim, Hyun Jung; Jung, Myung Eun; Son, Eun-Jung; Pae, Ae Nim; Kim, Jeongmin; Lee, Jinhwa Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6439 - 6442

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被引用次数: 17

摘要

Pyrimidine usually has good pharmacokinetic properties as a drug substance and considerable efforts have been devoted to develop pyrimidine derivatives into drug candidates. Arylpiperazine-containing pyrimidine 4-carboxamide derivatives were synthesized and evaluated for binding to serotonin receptors and transporter. Pyrimidine derivatives showed good antidepressant activity in FST (forced swimming test) animal ...