Synthesis of 2, 3??dihydrospiro [benzofuran??2, 4′??piperidines] and 2, 3??dihydrospiro [benzofuran??2, 3′??pyrrolidines]

…, BA Gardner, J Strupczewski

文献索引：Effland, Richard C.; Gardner, Beth Ann; Strupczewski, Joseph Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 811 - 814

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被引用次数: 8

摘要

Abstract The synthesis of 2, 3-dihydrospiro [benzofuran-2, 4′-piperidines] 3 and 2, 3- dihydrospiro [benzofuran-2, 3′]-pyrrolidine] 6 is described. The synthesis was achieved by a Grignard reaction of a 2-fluorobenzylhalide with an appropriate cycloazaalkyl ketone to yield the tertiary alcohols 1 and 4. Subsequent intramolecular displacement of the aromatic fluoride by the derived alkoxides provided the novel system.