Catalysis letters

Acetone cyanohydrin: a convenient alternative of toxic sodium cyanide/acetic acid for oxidative cyanation of tertiary amines

S Verma, SL Jain, B Sain

文献索引：Verma, Sanny; Jain, Suman L.; Sain, Bir Catalysis Letters, 2011 , vol. 141, # 6 p. 882 - 885

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被引用次数: 21

摘要

Abstract Acetone cyanohydrin was found to be a facile, convenient and comparatively safer alternative to toxic sodium cyanide/acetic acid system for generating in situ HCN for the oxidative cyanation of tertiary amines to α-aminonitriles in high yields with hydrogen peroxide using RuCl 3 as catalyst. In addition organic nature of acetone cyanohydrin makes it more suitable for an organic transformation since it is readily soluble in reaction medium ...