Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

H Tang, Y Yan, Z Feng, RK de Jesus, L Yang…

文献索引：Tang, Haifeng; Yan, Yan; Feng, Zhe; De Jesus, Reynalda K.; Yang, Lihu; Levorse, Dorothy A.; Owens, Karen A.; Akiyama, Taro E.; Bergeron, Raynald; Castriota, Gino A.; Doebber, Thomas W.; Ellsworth, Kenneth P.; Lassman, Michael E.; Li, Cai; Wu, Margaret S.; Zhang, Bei B.; Chapman, Kevin T.; Mills, Sander G.; Berger, Joel P.; Pasternak, Alexander Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 20 p. 6088 - 6092

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被引用次数: 13

摘要

A new series of thiazole-substituted 1, 1, 1, 3, 3, 3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose- dependent decreases in food intake and body weight in obese mice. Acute treatment with ...