4-Aminopyridine derivatives with antiamnesic activity

…, A Leoni, A Locatelli, R Morigi, M Rambaldi…

文献索引：Andreani, Aldo; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Pietra, Claudio; Villetti, Gino European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 77 - 82

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被引用次数: 38

摘要

Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected ...