Tetrahedron Letters

A chemo-enzymatic cascade for the one-pot synthesis of 1-deoxy-d-xylulose 5-phosphate and 1-deoxy-d-xylulose

SB Dai, J Liao, J Tian, H Li, WY Gao

文献索引：Dai, Shao-Bo; Liao, Juan; Tian, Jie; Li, Heng; Gao, Wen-Yun Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4809 - 4812

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被引用次数: 1

摘要

A chemo-enzymatic cascade for the one-pot preparation of 1-deoxy-d-xylulose 5-phosphate (DXP) and 1-deoxy-d-xylulose (DX) from stable, cheap, and easily available starting material R-glycidol is reported. The epoxide ring of R-glycidol was opened with phosphate to generate l-glycerol 3-phosphate, which was subsequently converted into the target molecules by combination of multi-enzymatic reactions in the same flask with purified ...