Antimalarial drugs. 60. Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl) …

…, JL Johnson, SJ Kesten, DJ McNamara…

文献索引：Werbel; Cook; Elslager; Hung; Johnson; Kesten; McNamara; Ortwine; Worth Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 924 - 939

全文：HTML全文

被引用次数: 51

摘要

A series of 54 (7-chloro-4-quinolinyl) amino]-3-[(alkylamino) methyl][l, l'-biphenyl]-2-ols and N”-oxides was prepared from the substituted 1-phenyl-2-propanones proceeding through the &nitro [l, l'-bipheny1]-2-01~, the corresponding amino, and acetamido derivatives to the N-[5-[(alkylamino) methyl]-6-hydroxy [l, l'-biphenyl]-3-yl] acetamides and final condensation with 4, 7-dichloroquinoline or the N-oxide. In a quantitative structure-activity relationship ...

~96%

~84%

~97%

~24%

~38%

~94%

Aromatic acetonylation promoted by manganese (III) and ceriu...

[Kurz, Michael E.; Baru, Vijayalakshmi; Nguyen, P-Nhi Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1603 - 1607]

Electrofluoration en position benzylique dans le sulfolane

[Laurent, Eliane; Marquet, Bernard; Tardivel, Robert Journal of Fluorine Chemistry, 1990 , vol. 49, # 1 p. 115 - 126]

The synthesis and pharmacological actions of ortho-substitut...

[Schumann,E.L. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 3, p. 567 - 582]