Tetrahedron letters

Alternative synthetic routes to 2′, 3′-didehydro-2′, 3′-dideoxy-5-hydroxymethyluridine

R Chung, KS Anderson

文献索引：Chung, Raymond; Anderson, Karen S. Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8361 - 8363

全文：HTML全文

被引用次数: 6

摘要

Several 2′,3′-dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides have been used for the treatment of patients with human immunodeficiency virus (HIV). These nucleosides, in their 5′-triphosphate form, inhibit the polymerization of proviral DNA facilitated by HIV reverse transcriptase. 2′,3′-Dideoxynucleosides that are FDA-approved for clinical use include 2′,3′-dideoxycytidine (ddC), 2′,3′-dideoxyinosine (ddI) and ...