Organic letters

Silylation-based kinetic resolution of monofunctional secondary alcohols

CI Sheppard, JL Taylor, SL Wiskur

文献索引：Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L. Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797

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被引用次数: 42

摘要

The nucleophilic small molecule catalyst (−)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.