Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca 2+-activated K+ channels

…, L Arifhodzic, CR Ganellin, DH Jenkinson

文献索引：Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H. European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923

全文：HTML全文

被引用次数: 1

摘要

Previously, quinolinium-based tetraazacyclophanes, such as UCL 1684 and UCL 1848, have been shown to be extraordinarily sensitive to changes in chemical structure (especially to the size of the cyclophane system) with respect to activity as potent non-peptidic blockers of the small conductance Ca2+-activated K+ ion channels (SKCa). The present work has sought to optimize the structure of the linking chains in UCL 1848. We report the synthesis ...