Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

…, SC Willies, I Rowles, A Frank, G Grogan…

文献索引：Ghislieri, Diego; Green, Anthony P.; Pontini, Marta; Willies, Simon C.; Rowles, Ian; Frank, Annika; Grogan, Gideon; Turner, Nicholas J. Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10863 - 10869

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被引用次数: 81

摘要

The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine chemical industries. This challenge is highlighted by the estimate that 40–45% of drug candidates contain a chiral amine, fueling a demand for broadly applicable synthetic methods that deliver target structures in high yield and enantiomeric excess. Herein we ...