Antitumor Activity of 5-Aryl-2, 3-dihydroimidazo [2, 1-a] isoquinolines

WJ Houlihan, PG Munder, DA Handley…

文献索引：Houlihan, William J.; Munder, Paul G.; Handley, Dean A.; Cheon, Seung H.; Parrino, Vincent A. Journal of Medicinal Chemistry, 1995 , vol. 38, # 2 p. 234 - 240

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被引用次数: 39

摘要

A series of 5-aryl-2, 3-dihydroimidazo [2, l-ulisoquinolines previously reported to be platelet activating factor (PAF) receptor antagonists were evaluated for potential antitumor activity. Several compounds, such as the 5-(4 '-tert-butylphenyl)(65), 5-[4 '-(trimethylsilyl) phenyll (69), and 5-(4 '-cyclohexylphenyl)(71) analogs showed very good cytotoxicity against several tumor cell lines. 5-[4'-(Piperidinomethyl) phenyll-2, 3-dihydroimidazo [2, l- ...