Azapeptides are known inhibitors of several serine and cysteine proteases. In seeking different classes of inhibitors for the HCV serine protease, a series of novel azapeptide- based inhibitors were investigated which incorporated noncleavable P1/P1'aza-amino acyl residues. Extensive SAR studies around the P1/P1'aza-amino acyl fragment resulted in the identification of potent and selective inhibitors. Using NMR studies, we have shown that ...
